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Istradefylline 40 mg/day elevated peak concentrations and AUC of CYP3A4 substrates in clinical trials. This outcome wasn't noticed with istradefylline twenty mg/working day. Consider dose reduction of delicate CYP3A4 substrates.modafinil will reduce the extent or influence of fruquintinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism.

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